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Saturday, January 3, 2009

Potent Anti-Inflammatory 5-LOXIN

Researchers discovered that 3-O-acetyl-11-keto-beta-boswellic acid (AKBA), trade name 5-LOXIN, fights osteoarthritis. It is believed that it does this by reducing inflammation. It combats inflammation by selectively inhibiting 5-lipoxygenase (5-LOX), which is a byproduct of arachidonic acid. (Note 1.) Boswellia extract has been found to genetically influence at least 113 genes, reducing inflammation. (Note 2.)

References
  1. "A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee." Krishanu Sengupta, Krishnaraju V Alluri, Andey Rama Satish, Simanchala Mishra, Trimurtulu Golakoti, Kadainti VS Sarma, Dipak Dey and Siba P Raychaudhuri. Arthritis Research & Therapy 2008, 10:R85. doi:10.1186/ar2461. http://arthritis-research.com/content/10/4/R85. (Accessed 12/28/08.)
  2. "Human Genome Screen to Identify the Genetic Basis of the Anti-inflammatory Effects of Boswellia in Microvascular Endothelial Cells." Sashwati Roy, Savita Khanna, Hiral Shah, Cameron Rink, Christina Phillips, Harry Preuss, Gottumukkala V. Subbaraju, Golakoti Trimurtulu, Alluri V. Krishnaraju, Manashi Bagchi, Debasis Bagchi, Chandan K. Sen. DNA and Cell Biology. April 1, 2005, 24(4): 244-255. doi:10.1089/dna.2005.24.244. http://www.liebertonline.com/doi/abs/10.1089%2Fdna.2005.24.244. (Accessed 12/28/08.)

1 comment:

JointPainFree.Me said...

Great post! This anti-inflammatory really does work. If anyone is interested in trying 5-Loxin, we have reviewed a product called Flexarite that contains it and many other all natural ingredients on our website www.JointPainFree.Me
Check it out.