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Tuesday, September 2, 2008

Pregnenolone and NMDA Receptors

Research indicates that pregnenolone has two different, but complementary, effects on the brain. First it increases the activity of N-methyl-D-aspartate (NMDA) receptors, "which weaken with age, are involved in learning, memory, and alertness."1 Second, it reduces GABA, which inhibits nerve impulses. So preg revs up learning, memory and alertness while simultaneously increaseing nerve impulse activity. The result: a significant nootropic, or smart drug.2 Researchers found that: "The ability of the neuroactive steroid pregnenolone sulfate to alter N-methyl-D-aspartate (NMDA) receptor-mediated elevations in intracellular Ca2+ . . . was studied in . . . rat hippocampal neurons. . . . Pregnenolone sulfate . . . caused a concentration-dependent and reversible potentiation of the rise . . . in [Ca2+]i induced by NMDA."2 This indicates that the consumption of preg can significantly alter the parameters of intelligence. That's why it's referred to as a smart drug or nootropic.

  1. Pregnenolone and Mental Function. (Accessed Sept 2, 2008.)
  2. Irwin R. P.; Maragakis N. J.; Rogawski M. A.; Purdy R. H.; Farb D. H.; Paul S. M. 1992. “Pregnenolone sulfate augments NMDA receptor mediated increases in intracellular Ca2+ in cultured rat hippocampal neurons.” Neuroscience letters., vol. 141, no1, pp. 30-34.

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