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Wednesday, September 3, 2008

Pregnenolone Protects Brain against Excitoxins

Pregnenolone has been found by a number of different clinical studies to protect the brain against excitotoxins. In one study it was discovered that pregnenolone achieved its protective effect by being converted by the enzyme aromatase into estridol, which protect neurons.1 Another study found that "(i) pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology and (ii) prevention of glucocorticoid receptor (GR) localization to the nucleus may be involved in the observed neuroprotective effects of pregnenolone against glutamate neurotoxicity."2 In plain English this means that the hormone pregnenolone may protect against the development of age-related mental deterioration and neurodegenerative diseases such as Alzheimers and Parkinson's.

  1. Veiga S, Garcia-Segura LM, Azcoitia I.Neurobiol. 2003. Neuroprotection by the steroids pregnenolone and dehydroepiandrosterone is mediated by the enzyme aromatase. J Neurobiol. Sep 15;56(4):398-406. Instituto Cajal, C.S.I.C., E-28002 Madrid, Spain. (Accessed Sept. 2, 2008.)
  2. Gursoy, Erdal; Arturo Cardounel and Mohammed Kalimi. 2001. Pregnenolone Protects Mouse Hippocampal (HT-22) Cells against Glutamate and Amyloid Beta Protein Toxicity. Neurochemical Research, Vol. 26, No. 1, pp. 15–21. (Accessed Sept. 2, 2008.)


Jeff Iversen said...

This is interesting to know but what practical application does this have for those who would like to avoid Alzheimer's and Parkinson's disease? Does the body naturally make Pregnenolone? Is there a supplement? Can we get it in our food? What role does DHEA play in the whole mix?

William Cane said...

Yes, there is a supplement. Preg is not well absorbed orally. The best route is sublingual preg tablets, which are readily available online. Not available in food. Body's production of preg declines with age. Pregnenolone's effects are much more noticeable than DHEA and you will find that energy is boosted and vision and pattern recognition improve in dramatic and significant ways. I have posted extensively about preg on this site and a search in the search box on the top left of the page will produce all my posts for you. I can't recommend this highly enough.

William Cane said...

It's hard to say whether pregnenolone will definitively prevent Alzheimer's or Parkinson's but the research is suggestive. Certainly more research is needed. And yet the benefits of preg are so significant (mental improvement, enhanced creativity, improved vision, to name but a few) that those over 40 may wish to try it even before all the research is finished.