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Thursday, July 2, 2009

Synthetic Mesencephalic Enhancer Regulation

In the brain there are certain neurons that talk to one another. Drugs like amphetamine and methamphetamine add noise to the talk by releasing additional neurotransmitters.5 But a new class of drugs can increase the volume of such neuronal talk: these substances are called synthetic mesencephalic enhancer regulators.4 Exciting new research by J. Knoll and others indicates that it is possible, through "prophylactic administration of a synthetic enhancer substance," to delay the aging of the brain.1 One such substance is deprenyl.2 Another, even stronger enhancer substance, is BPAP. Enhancer substances work in extremely low doses.6 (Photo: Professor Joseph Knoll, M.D., Ph.D.)

References
  1. Knoll J. Neurochem Res. 2003 Aug; 28(8):1275-97. Enhancer regulation/endogenous and synthetic enhancer compounds: a neurochemical concept of the innate and acquired drives. http://www.ncbi.nlm.nih.gov/pubmed/12834268 (accessed 6/30/09).
  2. The enhancer action of deprenyl works at a much lower concentration than that needed for MAO-B inhibition. See, Peter Gaszner, Ildikó Miklya. 2004. “Use of the synthetic enhancer substances (-)-deprenyl and (-)-bpap in major depression.” Neuropsychopharmacologia Hungarica, VI/4; 210-220. http://www.mppt.hu/pdf/0404_KOZL5.pdf (accessed 6/30/09).
  3. Knoll, József. 2005. The Brain and Its Self : A Neurochemical Concept of the Innate and Acquired Drives. Berlin and New York: Springer.
  4. I. Miklyaa, B. Knolla and J. Knoll. 2003. "A pharmacological analysis elucidating why, in contrast to (-)-deprenyl (selegiline), α-tocopherol was ineffective in the DATATOP study.
    Life Sciences. Volume 72, Issue 23, 25 April, Pages 2641-2648. doi:10.1016/S0024-3205(03)00174-7 (accessed July 1, 2009).
  5. Knoll, J. 1998. "(-)Deprenyl (selegiline), a catecholaminergic activity enhancer (CAE) substance acting in the brain." Pharmacology & Toxicology. Vol. 82, No. 2, pp. 57-66.
  6. Denes L, Szilágyi G, Gál A, Bori Z, Nagy Z. 2006. Life Sci. Aug 8; 79(11):1034-9. "Cytoprotective effect of two synthetic enhancer substances, (-)-BPAP and (-)-deprenyl, on human brain capillary endothelial cells and rat PC12 cells" http://www.ncbi.nlm.nih.gov/pubmed/16624331 (accessed July 1, 2009).

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