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Tuesday, April 20, 2010

Is DHEA Hepatocarcinogenic?

This post addresses the question of whether DHEA might be hepatocarcinogenic (a cause of liver cancer) in humans. Concern was raised when researchers at Oregon State University fed DHEA to trout and noted increased liver cancer.1 Stephen A. Cherniske commented that trout is "an organism that does not even produce DHEA naturally." He further said, "Such data [about trout liver cancer] would be useful only if there were indications that the same thing might occur in humans. But in a review of more than 5,500 studies published on DHEA, not one has shown that DHEA stimulates cancer growth. In fact, DHEA has been used successfully in the treatment of cancer."2 (Photo: Stephen Cherinske) References
  1. "Modulation of aflatoxin-B1 hepatocarcinogenesis in trout by dehydroepiandrosterone: initiation/post-initiation and latency effects." Orner GA, Hendricks JD, Arbogast D, Williams DE. Carcinogenesis. 1998 Jan. 19(1):161-7.
  2. "The DHEA Debate: A critical review of clinical and experimental data. Stephen Cherniske. LE Magazine. March 2004. Online at http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_01.htm. Cherniske quote from: http://www.lef.org/magazine/mag2004/mar2004_cover_dhea_02.htm.

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