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Friday, April 2, 2010

How Does Beta Sitosterol Work?

Beta sitosterol works through numerous pathways, one of which is to induce apoptosis (cell death) of cancer cells. "There is evidence that phytosterols inhibit the growth of estrogen-independent breast cancer MD Anderson Cancer Center (MDA)-MB-231 (MDA-MB-231) cells and androgen-dependent prostate cancer lymphnode cancer cell of the prostate (LNCaP) cells by initiating apoptosis. Beta-Sitosterol (16 umol/L) stimulates apoptosis in MDA-MB-231 cells
(63) and LNCaP cells (41,64) in vitro." The researchers further stated that oral beta sitosterol "lowered circulating E2 levels."

  1. "B-Sitosterol, B-Sitosterol Glucoside, and a Mixture of B-Sitosterol and B-Sitosterol Glucoside Modulate the Growth of Estrogen-Responsive Breast Cancer Cells In Vitro and in Ovariectomized Athymic Mice." Young H. Ju, Laura M. Clausen, Kimberly F. Allred, Anthony L. Almada, and William G. Helferich. J. Nutrition.

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