Subscribe

RSS Feed (xml)

Powered By

Skin Design:
Free Blogger Skins

Powered by Blogger

Monday, March 28, 2011

apoA-IMilano reduces arterial plaque

40 people in Milan have been found to eat lots of fat and yet have very low HDL, the protective cholesterol. Researchers thought they would have clogged arteries. It turns out that they had the cleanest clearest arteries ever discovered! Doctors attribute this to apoA-IMilano, a rare chemical they had in their blood. Now doctors are excited because by introducing this chemical into people with clogged arteries they can quickly reduce the clogged plaque! If you have heart disease because of clogged arteries, it may now be possible to reverse the condition! Perviously it was thought that very few substances--for example, the tocotrienol form of vitamin E--could reverse the buildup of arterial plaque (a process known as reverse-cholesterol transport).

(Photo: Dr. Prediman K. Shah MD)

References
  1. Clinical lipidology: a companion to Braunwald's heart disease. Christie M. Ballantyne. Elsevier Health Sciences, 2009, 584 pages, p. 52.
  2. Therapeutic Lipidology. Michael Davidson. p. 188. Humana Press, 2007, 487 pages. Refers to it as a "rare, fascinating polymorphism of apoA-I."
  3. "Potential Heart Disease Breakthrough: Arteries Unclog Fast With Revolutionary Cholesterol Treatment." Daniel J. DeNoon. WebMD Health News. Nov. 4, 2003. http://www.webmd.com/heart-disease/news/20031104/potential-heart-disease-breakthrough (accessed March 28, 2011).
  4. Applied Radiology. Volume 36, Number 12, December 2007. "Utility of 64-slice CT to monitor changes in atheroma volume: A pilot study." Borja Ibanez, MD. http://www.appliedradiology.com/Issues/2007/12/Supplements/Utility-of-64-slice-CT-to-monitor-changes-in-atheroma-volume--A-pilot-study.aspx (accessed March 28, 2011).
  5. Curr Opin Lipidol. 2004 Dec;15(6):645-9. "Human apolipoprotein A-I and A-I mimetic peptides: potential for atherosclerosis reversal." Navab M, Anantharamaiah GM, Reddy ST, Van Lenten BJ, Datta G, Garber D, Fogelman AM.
  6. "The Milano mutation: A rare protein mutation offers new hope for heart disease patients." Dan Krotz. http://www.eurekalert.org/features/doe/2002-05/dbnl-tmm061302.php (accessed March 28, 2011).
  7. Bio of researcher Dr. Prediman K. Shah MD. http://www.cedars-sinai.edu/Bios---Physician/P-Z/Prediman-K-Shah-MD.aspx (accessed March 28, 2011).

No comments: